The purpose of this literature review is to investigate the effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) compared with metabolic surgery in achieving weight loss among individuals living with obesity and type 2 diabetes (T2D) mellitus. A total of 498 citations were retrieved from previous studies that met prespecified inclusion criteria focusing on adult populations with obesity and T2D. Our findings indicate that bariatric/metabolic surgery results in the greatest reductions in body weight and body mass index (BMI). Both treatment modalities are effective in reducing glycosylated hemoglobin (HbA1c) levels, cardiovascular (CV) risk, morbidity, and mortality. GLP-1 RAs appear to represent a promising therapeutic option for individuals with obesity and diabetes who meet the criteria for bariatric surgery (BS). Ultimately, the individualization of treatment remains the cornerstone for providing the best possible care in managing this population.
doi: 10.17756/jocd.2025-055
Citation: Maggiorani L, Esposito FA, Maldonado S, Gutierrez MG, Usta J, et al. 2025. Effectiveness of Glucagon-like Peptide-1 Receptor Agonists in Patients with Obesity and Type 2 Diabetes vs Metabolic Surgery for Weight Loss Achievement. J Obes Chronic Dis 9(1): 31-37.
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