Objective: To investigate if treating OSA with CPAP improves the efficacy of a 16-week calorie restriction weight loss program in patients with obesity.
Methods: We conducted a retrospective study from 1/1/2014 to 8/31/2017. Patients were eligible if they were 18-65 years old, BMI >= 30 and < 50, and underwent a weight loss program obtained by calorie restriction (800 Kcal/day) for the first 8 weeks and then 500 Kcal/day deficit diet for the second 8 weeks.
Results: Total 300 patients were divided into asymptomatic patients (OSA-A, n = 89), symptomatic OSA (OSA-S, n = 164), and OSA on CPAP treatment (OSA-T, n = 47) groups. At the end of 16 weeks, the absolute weight loss of the OSA-T group was significantly greater than that of the OSA-S and OSA-A groups (-12.1 ± 5.9 vs. -9.5 ± 5.5 vs. -8.7 ± 5.3 kg, P < 0.01). A correlation of CPAP treatment to the absolute weight loss (Spearman’s correlation coefficient -0.181, P = 0.013) was established after adjustment of body weight, age and gender.
Conclusions: Our results suggest that the combination of weight loss and CPAP treatment should be considered for patients with obesity and OSA.
Citation: Mao Y, Ambrogini E, Lendel I, Goulden P. 2019. Treating Obstructive Sleep Apnea with Continuous Positive Airway Pressure May AidWeight Loss in Patients with Obesity on a Calorie Restriction Diet. J Obes Chronic Dis 3(2): 42-48.